Systemic Lupus Erythematosus (SLE) – Overview

Characterized by periods of flare-ups and remissions, SLE often leads to significant health challenges and a decrease in quality of life. Its onset is influenced by a combination of genetic, environmental, and hormonal factors. While it can occur at any age, SLE is most commonly diagnosed in women of reproductive age. Treatment primarily focuses on controlling symptoms, reducing flare-ups, and preventing irreversible damage to organs, though there is a growing demand for more precise and effective treatment options.

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SLE Epidemiological Segmentation (2020–2034) – 7MM

• Total Diagnosed Prevalent Cases
  
  

• Gender-Specific Diagnosed Prevalence
  
  

• Age-Specific Diagnosed Prevalence
  
  

• Severity-Based Diagnosed Cases
  
  

• Total Treated Cases
  
  

SLE Epidemiology – 2023 Highlights

In the 7MM, Spain had the highest number of diagnosed prevalent cases, followed by the UK and Germany.

Individuals aged 40–59 years accounted for approximately 40% of diagnosed cases, highlighting a major burden within this age group.

In Spain, nearly half of the diagnosed cases were categorized as moderate in severity, indicating a significant treatment need in this population.

Systemic Lupus Erythematosus Market Overview

The SLE market is experiencing significant changes, driven by scientific advancements and next-generation therapies that provide a deeper understanding of the disease's mechanisms.

Market Drivers

• Innovative drugs such as Lanalumab, Telitacicept, and SOTYKTU are emerging, showing the potential to improve patient outcomes by targeting specific immune pathways.
  
  

• Increased awareness of the disease and advancements in diagnostic practices are leading to earlier detection and better patient management, contributing to market growth.
  
  

Market Challenges

• The heterogeneous nature of SLE complicates clinical trial designs and creates challenges in predicting the effectiveness of treatments.
  
  

• High treatment costs and limited access to advanced therapies, particularly in low-resource settings, remain significant barriers to broader adoption.

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Emerging SLE Therapies

• Lanalumab
  
  

• Telitacicept
  
  

• GAZYVA
  
  

• SOTYKTU
  
  

• RINVOQ
  
  

• Other investigational agents
  
  

Leading Companies in the SLE Market

• Biogen
  
  

• Novartis
  
  

• MorphoSys
  
  

• Idorsia Pharmaceuticals
  
  

• Viatris
  
  

• RemeGen
  
  

• UCB Pharma
  
  

• Genentech
  
  

• Bristol Myers Squibb
  
  

• AbbVie
  
  

• Other key stakeholders

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