Sickle Cell Disease (SCD) – Overview

Sickle Cell Disease (SCD) is a genetic blood disorder caused by a mutation in the hemoglobin gene, resulting in the production of abnormal hemoglobin S.

Health Apr 21, 2025 16 Add to Reading List

This leads to the formation of crescent-shaped, rigid red blood cells that obstruct blood flow and reduce the supply of oxygen to tissues. The disease is linked to chronic pain, anemia, an increased risk of infections, organ damage, and other severe complications. SCD predominantly affects people of African, Mediterranean, Middle Eastern, and Indian heritage. Treatment approaches aim to manage symptoms, prevent complications, and improve the quality of life through advanced treatments and comprehensive care.

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Epidemiological Segmentation of SCD (2020–2034) – 6MM

Total Prevalence
Diagnosed Prevalence
Prevalence by SCD Type
Number of Treated Cases

SCD Epidemiology (2023 Insights)
As of 2023, there were approximately 161,000 prevalent cases of Sickle Cell Disease across the six major markets (6MM).

The United States accounted for about 65% of these cases, indicating a significant burden.

Within the U.S., the highest prevalence was seen in the 18–44 age group, highlighting the impact of the disease on young, working-age individuals.

SCD Market Overview
The Sickle Cell Disease market across the 6MM was valued at around USD 650 million in 2023.

Market Drivers

Advancements in gene-editing technologies and disease-modifying therapies are transforming the treatment landscape for SCD, offering the potential for lasting benefits.
Growing awareness, earlier diagnosis, and enhanced support from governments and advocacy organizations are contributing to market growth and improved access for patients.

Market Challenges

High treatment costs and limited healthcare infrastructure in low-income regions restrict access to advanced therapies.
Regulatory hurdles and clinical trial complexities may slow the development and approval of new treatments.

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Promising Emerging Therapies